Working with solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:
Our group experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in synthetic cells that may autonomously divide. Our primary desire lies in mobile division, chromatin construction, and spatial control.
Again in 1991, Sumio Iijima of the NEC Company experienced claimed the synthesis of carbon nanotubes. Band composition calculations prompt that these nanotubes could show metallic band conduction. This is able to be an important gain around the conducting polymers we experienced explored, which ended up, in actual fact, disordered semiconductors featuring basically variable-vary hopping conductivity.
Our work was rapidly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. Within just a few months, we were in the position to measure transportation through someone single-walled carbon nanotube. Determined by reduced-temperature experiments by a superb PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
We use nanofabricated microfluidic buildings to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental purpose of spatial confinement for the molecular and mobile degree. Our assignments contain the next:
Dynamic ParB–DNA interactions initiate and preserve a partition condensate for bacterial chromosome segregation
Let's say, rather than applying typical leading-down silicon electronics, transistors may very well be developed from The underside up making use of one natural molecules given that the switching factors? This concept, which became The idea of today’s discipline of molecular electronics, first emerged while in the 1970s.
‘The fantastically refined way wherein features in mother nature operate under no circumstances ceases to amaze me. If we clear up the puzzle of how daily life came into being, I expect that my amazement within the complexity of development could have elevated and with it my awe for the greatness of your Creator.’
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More not long ago his analysis has centered on learning chromatin composition and mobile cees dekker division with bacteria on chip, even though he can also be seeking to in the end Establish synthetic cells from The underside up.
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At last, I'll briefly sketch many of our Suggestions to discover the creating of synthetic cells, exclusively our 1st techniques to determine artificial mobile division.